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Procedure: Internal Review, Research Proposals and Study Protocols.
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Age-dependent formation of TMEM106B amyloid filaments in human brains.
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2014 Joint ACTRIMS-ECTRIMS Meeting (MSBoston 2014) MS Journal Online.
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CSF1R signaling is a regulator of pathogenesis in progressive MS.
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Procedure: Internal Review, Research Proposals and Study Protocols.

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Age-dependent formation of TMEM106B amyloid filaments in human brains.

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2014 Joint ACTRIMS-ECTRIMS Meeting (MSBoston 2014) MS Journal Online.

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The PI uploads the requested project documents and captures key project information and details relating to resourcing, ethics, and biosafety online. The form is sent online to Departmental Research Finance Staff (Budget Reviewer) to complete project-related finance information that was discussed with the PI prior to submission of the form. CSF1R signaling is upregulated in progressive MS. CSF1R is a type III receptor tyrosine kinase expressed on microglia and macrophages. Elevated signaling downstream of CSF1R has been implicated in deleterious microglial function in various neurodegenerative diseases 33-35.To understand CSF1R signaling in MS, we examined CSF1R and CSF1 expression in post-mortem brain tissue from progressive.

CSF1R signaling is a regulator of pathogenesis in progressive MS.

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